Antimicrobial Activity of Secondary Metabolites from Chaetomium Cupreum-ss02 Isolated from Soil

The antimicrobial efficacy of methanol, ethyl acetate, chloroform and butanol extracts of fungus Chaetomium cupreum was determined by employing well diffusion and broth micro-dilution techniques. Chaetomium species are the largest genus of saprophytic ascomycetous fungus, which belongs to the class Sordariomyetes and family Chaetomiaceae. Ethyl acetate and butanol extracts exhibited antibacterial activity against four bacteria, Staphylococcus aureus, Salmonella typhi, Proteus vulgaris, Bacillus subtilis tested. In the butanol extract, all the four bacteria exhibited antibacterial activity with zone of inhibition ranging from 12.0 to 18.5mm at 0.5mg/ml concentration. In the butanol extract, the most susceptible organism was found to be B. subtilis followed P. Vulgaris,S. typhi and S. aureus Whereas in ethyl acetate extract, all the four bacteria exhibited antibacterial activity with zone of inhibition ranging from 13.5 to 17.0 mm at 0.5mg/ml concentration. The most susceptible organism was to found be P. Vulgaris followed by B. subtilis, S. typhi and S. aureus